Dr. Lena Bouman

Lena Bouman studied biology in Marburg and Tübingen, specialising in cell biology and genetics. She was a visiting research fellow for a year at the Institut Curie in Paris and at Rockefeller University in New York. The topic of her doctoral thesis in the group of Prof. Dr. Konstanze Winklhofer (Max Planck Institute of Biochemistry and Ludwig-Maximilians-Universität in Munich/Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)), was the molecular mechanisms of Parkinson's disease.

At CAS, she is responsible for natural sciences and medicine. She also coordinates the institute's exhibition programme “Kunst am CAS”.

Publications

Editor of the catalogues published as part of ‘Art at CAS’; highlights include: Art catalogue for ‘10 Jahre Kunst am CAS’ (2018); catalogue for the exhibition ‘Henri Matisse – Jazz’ (winter semester 2024/25).

Contribution to the book: Meyer, A./Schleissing, S. (eds.): Projektion Natur. Grüne Gentechnik im Fokus der Wissenschaften, (Umwelt und Gesellschaft, Bd. 12), Göttingen 2014.

• Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
  Bouman L., Schlierf A., Lutz A.K., Shan J., Deinlein A., Kast J., Galehdar Z., Palmisano V., Patenge N., Berg D., Gasser T., Augustin R., Trümbach D., Irrcher I., Park D.S., Wurst W., Kilberg M.S., Tatzelt J., Winklhofer K.F.
  Cell Death Differ. 2010 Nov 26.
• Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
  Lutz A.K., Exner N., Fett M.E., Schlehe J.S., Kloos K., Lämmermann K., Brunner B., Kurz-Drexler A., Vogel F., Reichert A.S., Bouman L., Vogt-Weisenhorn D., Wurst W., Tatzelt J., Haass C., Winklhofer K.F.
  J Biol Chem. 2009 Aug 21;284(34):22938-51.
• Parkin mediates neuroprotection through activation of IKK/NF-κB signaling.
  Henn I.H., Bouman L., Schlehe J.S., Schlierf A., Schramm J.E., Nakaso K., Culmsee C., Berninger B., Krappmann D., Tatzelt J., Winklhofer K.F.
  J. Neurosci. 2007 Feb 21;27(8):1868-78.
• Ewing's sarcoma cells: up-regulation by interferon.
  Bouman L., Sanceau J., Rouillard D., Bauvois B. Gamma-Glutamyl transpeptidase expression in.
  Biochem J. 2002 Jun 15; 364(Pt 3):719-24.